Sleep problems are a common problem for people with schizophrenia. They can include insomnia, excessive sleepiness, and trouble getting consistent sleep routines.
Antipsychotic medications may help with some of these sleep problems, but they can also cause some to worsen. One reason is that they block the D2 receptors in the brain. This can trigger restless leg syndrome and periodic limb movement disorder.
What is a wakefulness-inducing agent?
A wakefulness-inducing agent is a cocktail of smart pills that is aimed at getting your brain to snooze. The best-known example is a stimulant, or in the clinical jargon a psychoactive substance. A wakefulness-inducing agent is not to be confused with a sleep aid, a non-stimulant, or a placebo. The aforementioned syllables should be administered only in the presence of a qualified medical professional and no more than once a day. Modvigil 200 Australia is a wakefulness-promoting agent, approved for the treatment of narcolepsy, sleep apnea, and shift work-induced sleep disorder.
How does a wakefulness-inducing agent work?
There is now an extensive body of research into sleep and circadian rhythm disruption (SCRD) in schizophrenia which has led to an understanding of how this can be a key factor in the development of the disorder. SCRD is a major symptom of schizophrenia and is often associated with a decrease in quality of life and the appearance of a number of other symptoms. Buy Artvigil Australia, It might help you stay alert during the day.
One of the most prominent features of this abnormality is a reduction in’sleep spindles’ on an EEG which measures electrical activity of the brain. This reduced brain wave pattern is a significant problem for people with schizophrenia because it has been shown to negatively impact on cognition and learning.
Smart pill -induced wakefulness can have a profound effect on EEG delta power, which is an important neurotransmitter. This is believed to be due to ‘down-scaling’ of the synaptic strengthening induced by prolonged waking.
How does a wakefulness-inducing agent help with schizophrenia?
Getting a good night’s sleep is an important part of being healthy, but it’s also vital for maintaining mental health. In particular, it is believed to be critical for the prevention of schizophrenia as well as a key element in the management of symptoms.
This is because a good nights sleep helps to reduce the incidence of both negative and positive symptoms in people with schizophrenia. Furthermore, sleep problems are associated with poorer patient quality of life scores.
In addition, a recent study in humans has found that an abnormality in the circadian clock is a significant factor in the development of schizophrenia. The most notable is a shift in the phase of the clock, with non-24 h periods and phase advances being common.
Although a plethora of hypnotic (sleep inducing) smart pills are available to treat this condition, few of them are effective enough to be of real use in the long term. This is largely due to the fact that many of these smart pills have the side effect of making people feel drowsy and irritable, which are particularly bad for patients with schizophrenia as they are prone to delusions and hallucinations.
Can a wakefulness-inducing agent help with insomnia?
It is well-known that disturbed sleep patterns are a common symptom of schizophrenia and can significantly interfere with an individual’s quality of life. It can also lead to a worsening of psychotic symptoms.
Disturbed sleep and wakefulness can be treated with a range of different pharmacotherapy options. However, these methods are often accompanied by side effects and may not be suitable for everyone.
Research shows that people with schizophrenia are more likely to experience chronic insomnia if they are taking antipsychotics, as the smart pills can affect the natural circadian rhythms of the brain. Furthermore, abruptly stopping antipsychotics can also have negative consequences for the quality of a person’s sleep and cause them to have more frequent ruminations during the night.
The EEG and brain gene-expression’signatures’ of the wake-promoting smart pills ( modafinil, and Armodafinil) were compared in three inbred strains of mice that differed significantly on their expression and regulation of sleep and wakefulness. We found that all smart pills induced high-frequency EEG components, which are reminiscent of those evoked by demanding cognitive tasks.